Premium
Identification of bla OXA‐128 and bla OXA‐129, two novel OXA‐type extended‐spectrum‐β‐lactamases in Pseudomonas aeruginosa , in Hunan Province, China
Author(s) -
Liu Wen'en,
Liu Xiaoyi,
Liao Jingzhong,
Zhang Yunli,
Liang Xianghui
Publication year - 2010
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.201000181
Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , biology , broad spectrum , pseudomonas , bacteria , chemistry , genetics , combinatorial chemistry
We collected 97 non‐repetitive carbapenemases‐sensitive clinical isolates of Pseudomonas aeruginosa in Human Province, China, during the period of October 2006 to January 2007. From these isolates, we identified two novel oxacillin‐hydrolysing (OXA) type extended‐spectrum‐β‐lactamases (ESBLs): bla OXA‐128 and bla OXA‐129, which contain the mutations of I89V from bla OXA‐56 and K134N from bla OXA‐10, respectively. Clinical isolates containing either bla OXA‐128 or bla OXA‐129 show resistance to cephamycin‐class antibiotics but sensitive to carbapenem‐class antibiotics. The occurrence of novel OXA‐type lactamases suggests a regional prevalent pattern of ESBLs Pseudomonas aeruginosa in this area. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)