Antimicrobial properties of a non‐toxic glycoprotein (WSG) from  Withania somnifera  (Ashwagandha) | Zendy

Girish K. S. | Zendy; Machiah K. D. | Zendy; Ushanandini S. | Zendy; Harish Kumar K. | Zendy; Nagaraju S. | Zendy; Govindappa M. | Zendy; Vedavathi M. | Zendy; Kemparaju K. | Zendy

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Antimicrobial properties of a non‐toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha)

Author(s) -

Girish K. S.,

Machiah K. D.,

Ushanandini S.,

Harish Kumar K.,

Nagaraju S.,

Govindappa M.,

Vedavathi M.,

Kemparaju K.

Publication year - 2006

Publication title -

journal of basic microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 54

eISSN - 1521-4028

pISSN - 0233-111X

DOI - 10.1002/jobm.200510108

Subject(s) - withania somnifera , antimicrobial , microbiology and biotechnology , chemistry , protease , aspergillus flavus , fusarium oxysporum , antibacterial activity , isorhamnetin , biology , biochemistry , bacteria , enzyme , antioxidant , flavonoid , botany , medicine , kaempferol , alternative medicine , pathology , genetics

A monomeric glycoprotein with a molecular mass of 28 kDa in SDS‐PAGE was isolated from the Withania somnifera root tubers. The protein designated WSG ( Withania somnifera glycoprotein) demonstrated potent antimicrobial activity against the phytopathogenic fungi and bacteria tested. Antifungal effect has been demonstrated in that WSG exerts a fungistastic effect by inhibiting spore germination and hyphal growth in the tested fungi. WSG showed potent antifungal activity against Aspergillus flavus , Fusarium oxysporum, F. verticilloides and antibacterial activity against Clvibacter michiganensis subsp. michiganensis. WSG is an acidic, non‐toxic (trypsin‐chymotrypsin) protease inhibitor. These results encourage further studies of WSG as a potential therapeutic agent for its antifungal activity. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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