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Antimicrobial properties of a non‐toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha)
Author(s) -
Girish K. S.,
Machiah K. D.,
Ushanandini S.,
Harish Kumar K.,
Nagaraju S.,
Govindappa M.,
Vedavathi M.,
Kemparaju K.
Publication year - 2006
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.200510108
Subject(s) - withania somnifera , antimicrobial , microbiology and biotechnology , chemistry , protease , aspergillus flavus , fusarium oxysporum , antibacterial activity , isorhamnetin , biology , biochemistry , bacteria , enzyme , antioxidant , flavonoid , botany , medicine , kaempferol , alternative medicine , pathology , genetics
A monomeric glycoprotein with a molecular mass of 28 kDa in SDS‐PAGE was isolated from the Withania somnifera root tubers. The protein designated WSG ( Withania somnifera glycoprotein) demonstrated potent antimicrobial activity against the phytopathogenic fungi and bacteria tested. Antifungal effect has been demonstrated in that WSG exerts a fungistastic effect by inhibiting spore germination and hyphal growth in the tested fungi. WSG showed potent antifungal activity against Aspergillus flavus , Fusarium oxysporum, F. verticilloides and antibacterial activity against Clvibacter michiganensis subsp. michiganensis. WSG is an acidic, non‐toxic (trypsin‐chymotrypsin) protease inhibitor. These results encourage further studies of WSG as a potential therapeutic agent for its antifungal activity. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)