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A mathematical model of Saccharomyces cerevisiae growth in response to cadmium toxicity
Author(s) -
Hietala Katie A.,
Lynch Miranda L.,
Allshouse John C.,
Johns Craig J.,
Roane Timberley M.
Publication year - 2006
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.200510061
Subject(s) - saccharomyces cerevisiae , exponential growth , yeast , toxicity , cadmium , cell growth , lag , growth model , biology , bacterial growth , biological system , microbiology and biotechnology , biophysics , chemistry , toxicology , mathematics , biochemistry , computer science , genetics , mathematical economics , bacteria , mathematical analysis , computer network , organic chemistry
Microbial growth can be described using models derived by differential equations, but available mathematical models have yet to adequately describe lag phase related cell growth or cell mortality in response to chemical toxicity. Lag phase cell behavior, however, dictates the onset of exponential growth and the number of actively growing cells available to initiate exponential growth, important factors in the success of remediation efforts. In this study, a five‐parameter polynomial ratio (PR) model was used to characterize the growth, from lag through stationary phase, of the yeast Saccharomyces cerevisiae in response to cadmium toxicity. The PR model used in this study has the advantages over standard mathematical models in the ability to represent the initial cell mortality observed when S. cerevisiae is exposed to increasing cadmium levels, up to 12 mg/l Cd, as well as following cell recovery and growth to stationary levels. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)