Control of pyrimidine biosynthesis in “ Pseudomonas alkanolytica ” ATCC 21034 | Zendy

West Thomas P. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Control of pyrimidine biosynthesis in “ Pseudomonas alkanolytica ” ATCC 21034

Author(s) -

West Thomas P.

Publication year - 2004

Publication title -

journal of basic microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 54

eISSN - 1521-4028

pISSN - 0233-111X

DOI - 10.1002/jobm.200310373

Subject(s) - biosynthesis , pyrimidine metabolism , pseudomonas , pyrimidine , chemistry , biochemistry , microbiology and biotechnology , bacteria , biology , enzyme , genetics , purine

The control of de novo pyrimidine biosynthesis in the industrially important patent strain “ Pseudomonas alkanolytica ” ATCC 21034 was investigated. Uracil supplementation of succinate‐grown “ P . alkanolytica ” cells produced the greatest depression of the de novo pyrimidine biosynthetic pathway enzyme activities. After the pyrimidine limitation of a “ P . alkanolytica ” orotate phosphoribosyltransferase mutant strain grown on succinate, the pyrimidine biosynthetic pathway enzyme activities were derepressed. The pyrimidine biosynthetic pathway enzyme aspartate transcarbamoylase in “ P . alkanolytica ” was inhibited by pyrophosphate, cytidine 5′‐triphosphate (CTP), uridine 5′‐triphosphate (UTP), and guanosine 5′‐triphosphate (GTP). (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research