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Effect of prostaglandin A 1 in porcine cells persistently infected with classical swine fever virus
Author(s) -
Pereira Freitas Tânia Rosária,
Caldas Lúcio Ayres,
Rebello Moacyr Alcoforado
Publication year - 2003
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/jobm.200310295
Subject(s) - virus , virology , prostaglandin , viral replication , cyclopentenone , biology , interferon , microbiology and biotechnology , chemistry , biochemistry , organic chemistry
Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A 1 (PGA 1 ) potently inhibited the replication of classical swine fever virus in cultures of PK‐15 cells. The highest non‐toxic dose (5 μg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA 1 was removed from persistently infected cells, the inhibition of virus replication was partially reverted.