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Recombinogenic activity of nalidixic acid for artificial hybrids but not for natural strains of Candida albicans : Evidence for the monoploidy of natural strains
Author(s) -
Sarachek A.
Publication year - 1983
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19830230608
Subject(s) - nalidixic acid , candida albicans , microbiology and biotechnology , hybrid , biology , natural (archaeology) , botany , antibiotic resistance , antibiotics , paleontology
Nalidixic acid induces segregation of auxotrophs from prototrophic hybrids of Candida albicans artifically produced by fusing complementing auxotrophic protoplasts. The auxotrophies recovered are limited to those introduced through the fusion process, and patterns of segregations for linked auxotrophic markers demonstrate the segregants are products mitotic cossing‐over. Nalidixic acid does not induce auxotrophies of any sort in clinical isolates of C. albicans. These findings are contrary to a current hypothesis that natural strains of C. albicans are diploid and heterozygous for a variety of auxotrophic mutations.