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Regulation der Citratsynthase bei fakultativ methylotrophen Bakterien
Author(s) -
MüllerKraft Gabriele,
Babel W.
Publication year - 1983
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19830230306
Subject(s) - citrate synthase , anabolism , citric acid cycle , biochemistry , pseudomonas , catabolism , bioenergetics , bacteria , atp synthase , chemistry , biology , enzyme , mitochondrion , genetics
Commonly the TCA cycle fulfils an anabolic and a catabolic function in case of aerobic chemo‐organoheterotrophic nutrition. In methylotrophic growth the TCA cycle is dispensable as a bioenergetic pathway. This is reflected by properties of citrate synthase in facultative methylotrophic bacteria. Two citrate synthases, a ‘chemoorganoheterotrophic’ one, which is inhibited by NADH (or ATP in Acetobacter MB 58), and a ‘methylotrophic’ one, which is not or less affected by energy indicators, were found in Pseudomonas oleovorans, Pseudomonas MS, Pseudomonas MA, and Acetobacter MB 58. The concentration of these citrate synthases depends on the manner of nutrition. Bacteria with ICL‐negative‐variant of the serine pathway and with ribulosebisphophate pathway seem to possess only a ‘chemoorganoheterotrophic’ citrate synthase. Possibly the anabolic function of this citrate synthase can be realized by metabolites.