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Anthracyclic products from Streptomyces erythromogenes nov. sp. Biotransformation of daunomycin (Dn) by an acellular preparation and synergism between Dn and some known antibiotics
Author(s) -
Abdallah Nadia M.,
Devys M.,
Barbier M.
Publication year - 1982
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19820220302
Subject(s) - mycelium , biotransformation , antibiotics , streptomyces , antimicrobial , bacillus subtilis , microbiology and biotechnology , chloramphenicol , strain (injury) , enzyme , penicillin , chemistry , biology , biochemistry , bacteria , stereochemistry , botany , genetics , anatomy
The filtrate broth as well as mycelium of the new strain Streptomyces erythrochromogenes nov. sp. isolated from Saudi Arabian soil, produce the antitumor antibiotic daunomycin 1 and two anthracyclic derivatives: 7‐deoxy 13‐dihydrodaunomycinone 2 and 7‐deoxy daunomycinone 4 . The biotransformation of 1 to 2 and 4 by an acellular enzyme preparation from the strain was found to be NADPH and/or NADH dependent. Mixtures of daunomycin 1 with chloramphenicol or penicillin showed superior antimicrobial activities against Bacillus subtilis ICC strain, than the individual antibiotics.