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Regulation of steroid 16α‐hydroxylation in Streptomyces olivoviridis
Author(s) -
Dlugoński J.,
Sedlaczek L.
Publication year - 1981
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19810210703
Subject(s) - hydroxylation , mycelium , steroid , streptomyces , enzyme , substrate (aquarium) , chemistry , biochemistry , biology , stereochemistry , hormone , bacteria , botany , genetics , ecology
The steroid 16α‐hydroxylase of Streptomyces olivoviridis was shown to be constitutive, but synthetized only in small amounts in the absence of cortisol. The induction of the enzyme with the steroidal substrate resulted in a distinct increase in the 16α‐hydroxylation rate. This increase in activity, however, could be demonstrated only in later phases of culturing, after the growth of the mycelium was completed. The possible mechanisms controlling the activity of the enzyme during the growth phase of the culture are discussed.