Premium
The induction of cytochrome P‐450 in Lodderomyces elongisporus
Author(s) -
Mauersberger S.,
Schunck W.H.,
Müller H.H.
Publication year - 1981
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19810210407
Subject(s) - cycloheximide , catabolite repression , tetradecane , inducer , chemistry , asymmetric induction , yeast , cytochrome , stereochemistry , alkyl , biochemistry , organic chemistry , catalysis , mutant , protein biosynthesis , gene , enzyme , enantioselective synthesis
In the alkane‐utilizing yeast strain Lodderomyces elongisporus cytochrome P‐450 is induced by aliphatic hydrocarbons and to a lesser degree also by some of their derivatives. Cycloheximide and glucose inhibit the induction process, the former by inhibition of cytoplasmic translation, the latter presumably by catabolite repression. Among the nearly 40 checked compounds tetradecane and 1‐tetradecene are the most effective inducers. The branching of the alkyl chain as well as the terminal introduction of electrophilic atoms decrease the induction effect.