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Inhibitor studies of phage T4 wild‐type and mutant DNA polymerases. III. Distamycin A, actinomycin D, adriamycin, daunomycin and ethidium
Author(s) -
Jantschak J.,
Schroeder Cornelia,
Jantschak J.
Publication year - 1980
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19800200904
Subject(s) - polymerase , dna polymerase , dna , microbiology and biotechnology , mutant , enzyme , chemistry , biology , biochemistry , gene
Adriamycin, daunomycin and ethidium, intercalating drugs which bind to double‐ as well as single‐stranded DNA, inhibit phage T4 antimutator mutant CB121 DNA polymerase more strongly than the T4 wild‐type and the mutator L98 polymerase. In contrast, all three enzymes are inhibited equally by distamycin A and actinomycin C. The latter two inhibitors bind only to double‐stranded DNA.