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Alcohol‐induced switching over of metabolic flux in Streptomyces noursei JA0 3890b
Author(s) -
Gräfe U.,
Schade W.,
Bocker H.,
Thrum H.
Publication year - 1979
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19790191006
Subject(s) - streptomyces , flux (metallurgy) , chemistry , alcohol , oxidative deamination , biochemistry , stereochemistry , organic chemistry , biology , enzyme , bacteria , genetics
Short‐chain alcohols, benzyl alcohol and Tween 20 were found capable of switching over the metabolic flux in Streptomyces noursei JA 3890b from the preference of oxidative deamination of alanine towards the reinforced acquisition of NH 4 + . These changes were correlated to the decrease of the ratio of saturated to olefinic fatty acids in the mycelium, suggesting that alcohols and other polar lipophilic compounds can interfere with the biosynthesis and the function of the cytoplasmic membrane in Streptomyces .