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Wirkung von Tridemorph auf Torulopsis candida B ERLESE
Author(s) -
Bergmann H.
Publication year - 1979
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19790190302
Subject(s) - respiration , antimycin a , chemistry , oligomycin , yeast , biochemistry , biology , botany , enzyme , electron transport chain , atpase
From the results of application of various inhibitors, or combinations of inhibitors to cell suspensions of the yeast Torulopsis candida and by determination of O 2 ‐consumption and growth rates it is concluded, that a main site of action of tridemorph is localized in the pathway of the respiratory chain. Tridemorph inhibits as well the respiration as the growth of T. candida depending on the concentration and the time of exposition. Tridemorph does not uncouple respiration but inhibits the uncoupled respiration to the same extent. Inhibition of respiration and growth by tridemorph is enhanced by suboptimal concentrations of antimycin A, oligomycin, rotenone, and 2,4‐dinitrophenole. That leads to the conclusion that these inhibitors essentially enlarge the permeability for tridemorph which can be more rapidly transported to the site of action.