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Elektronenoptische Untersuchungen zur Wirkung von 1‐[ p ‐(Methylnitrosamino)‐benzylidenamino]‐adamantan auf das Fowl‐Plague‐Virus (FPV) in Zellkultur
Author(s) -
Zöpel P.,
Tonew E.,
Ulbericht H.
Publication year - 1978
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19780180706
Subject(s) - pinocytosis , virus , cytoplasm , chemistry , penetration (warfare) , biology , fowl , virology , cell , biochemistry , endocytosis , paleontology , operations research , engineering
The adamantanamine derivative 1‐[ p ‐(methylnitrosamino)‐benzylidenamino]‐adamantane (MBAA) at a concentration of 40 μg/ml demonstrated no effect on adsorption of fowl plague virus (FPV) on chick embryonal cells. The penetration of the virions took place by means of pinocytosis. In the final stages of penetration the virions became gradually disintegrated. Under the influence of MBAA, after break‐down of the membrane of pinocytic vesicles a swollen part of the virus core remained in cytoplasm. The morphologically visible replication stages were completely blocked by MBAA. From these results it was concluded that the antiviral action of MBAA most probably depends on a block of virus replication between the final stages of the penetration process and the beginning of production of virus specific structural antigens.