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Physiologie und Biochemie der Streptomyceten XIII. Biosynthese von Paromomycin unter Einsatz von 14 C‐Glucose, ‐Glucosamin, ‐2‐Desoxystreptamin und ‐Ribose durch Streptomyces albus var. metamycinus nov. var.
Author(s) -
Reuter G.,
Köster H.,
Liebermann B.
Publication year - 1977
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19770170707
Subject(s) - paromomycin , chemistry , biosynthesis , glucosamine , decarboxylation , biochemistry , stereochemistry , ribose , enzyme , antibiotics , aminoglycoside , catalysis
Distribution of radioactivity in paromomycin ascertained after application of 14 C‐D‐glucose, 14 C‐D‐glucosamine, 14 C‐2‐deoxystreptamine, respectively, 14 C‐D‐ribose is taken as basis for a biosynthesis scheme: While ribose bound in the antibiotic originates from glucose by oxidation and following decarboxylation, glucosamine is formed via fructose‐6‐phosphate. Paromose I arises from glucosamine, but not the cyclohexan derivative 2‐deoxystreptamine, whose biosynthesis pathway is directly branching off glucose.