Premium
Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes P RAUSER
Author(s) -
Fleck W.,
Strauss D.,
Prauser H.,
Jungstand W.,
Heinecke H.,
Gutsche W.,
Wohlrabe K.
Publication year - 1976
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19760160704
Subject(s) - antimicrobial , antibiotics , chemistry , mycelium , streptomyces , bacteria , microbiology and biotechnology , in vivo , enzyme , biochemistry , in vitro , biology , botany , genetics
Lambdamycin‐producing strains were detected by means of the BIP test method. The isolation technique and the physicochemical and biological properties of lambdamycin, an antibiotic produced by Streptomyces glaucoachromogenes , are described. Lambdamycin is a yellow‐green pigment of the chromoglycoside type. Digitalose and fucose are the sugar components. The physicochemical properties of lambdamycin resemble those of chartreusin. However, the known biological activity is different. The antibiotic can be isolated from culture filtrates and from the mycelium by extraction with lower aliphatic alcohols. It can be purified by gel filtration methods. Lambdamycin displays antimicrobial activity, particularly against grampositive bacteria. Strains which produce enzymes inactivating different commercial antibiotics are also inhibited. Moreover, lambdamycin shows antiviral activity, as well as cancerostatic and ergotropic action in vitro and in vivo . The acute LD 50 of lambdamycin in mice after 21 days was > 125 mg/kg when administered intraperitoneally.