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Mutagenesis in bacteriophage T 7. I. Chemically induced mutagenesis
Author(s) -
Meyer M.
Publication year - 1976
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19760160407
Subject(s) - mutagenesis , hydroxylamine , mutation , bacteriophage , transition (genetics) , genetics , chemistry , host (biology) , biology , biochemistry , escherichia coli , gene
Abstract The mutagenesis in phage T 7 after MMS‐, HNO 2 ‐, hydroxylamine‐, 5‐BUdR‐, and 2‐AP‐treatment in relation to host controlled functions is investigated. There was no dependence of the induction of mutations on the character of the host strains ( rec, hcr ). A back mutation system ( amber system) and a forward mutation system (host range system) have been used. Substances which cause mainly transitions from GC to AT do not lead or only rarely lead to reversions of the amber system; but chemicals producing transitions from AT to GC do so.