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Wirkung von Distamycin A und Netropsin auf normale und zellwandlose Zellen von Escherichia coli W1655F +
Author(s) -
Schuhmann Edith,
Haupt Ina,
Thrum H.,
Taubeneck U.,
May Ursula
Publication year - 1974
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19740140407
Subject(s) - netropsin , bacteria , escherichia coli , antibiotics , stereochemistry , chemistry , microbiology and biotechnology , biology , biochemistry , dna , genetics , minor groove , gene
Distamycin A and netropsin are basic oligopeptide antibiotics. Though the chemical structure of both antibiotics is very similar, the action on grampositive and gramnegative bacteria is quite different. Distamycin A acts only on grampositive bacteria, while netropsin inhibits grampositive as well as gramnegative bacteria. Our experiments with the normal rod form and the stable protoplast type L‐form of E. coli W1655F + have shown that distamycin A inhibits gramnegative bacteria to the same extent as netropsin, when wall‐less L‐form‐ells were used. The normal rod cells were inhibited by netropsin only. That means that the wall prevents the penetration of distamycin A as reported earlier for the macrolid antibiotics, actinomycin C and kirromycin.