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Antimicrobial properties of fungal macrolide antibiotics
Author(s) -
Betina V.,
Mičeková Daniela
Publication year - 1972
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19720120502
Subject(s) - microbiology and biotechnology , candida albicans , botrytis cinerea , bacillus subtilis , aspergillus fumigatus , antimicrobial , biology , cytochalasin b , mucor , cytochalasin , antiprotozoal , biochemistry , bacteria , aspergillus , botany , in vitro , genetics , cytoskeleton , cell
Antibacterial, antifungal and antiprotozoal effects of curvularin, cyanein, monorden, and cytochalasins A, B and D were studied. Curvularin and cytochalasin B showed no inhibition of the microorganisms tested. Cyanein and cytochalasin D, besides their cytotoxicity, are antifungal antibiotics. Cytochalasin A inhibits growth of Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Candida albicans, Mucor corymbifer, Aspergillus fumigatus , and Botrytis cinerea. Monorden was active against B. subtilis, S. cerevisiae, C. albicans, B. cinerea , and also against Euglena gracilis . Cyanein, monorden, and cytochalasins A and D induce an intensive ramification of B. cinerea hyphae. Biological activity of the studied compounds is discussed in terms of their chemical structures.