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Flavomycoin, ein neues Polyenantibioticum aus Streptomyces roseoflavus. Produktion, Isolierung und Eigenschaften
Author(s) -
Schlegel R.,
Fügner Rosemarie,
Bradler Gertraud,
Thrum H.
Publication year - 1971
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19710110804
Subject(s) - polyene , streptomyces , mycelium , chemistry , stereochemistry , microbiology and biotechnology , botany , organic chemistry , biology , bacteria , genetics
The polyene antibiotic flavomycoin is produced by the Streptomyces strain JA 5068, which was named Streptomyces roseoflavus ARAI 1951 var. jenensis nov. var. because of its morphological and physiological properties. JA 5068 differs from the strains producing the similar antibiotics flavofungin and mycoticin, Streptomyces flavofungini URI et al. 1957 and Streptomyces ruber (KRAINSKY 1914) WAKSMAN et HENRICI 1948, respectively. Flavomycoin, C 41 H 68 O 10 · 2 H 2 O, represents a new type of carbonyl pentaene. It has been isolated from the mycelium by extraction with methanol and butanol. The yellow‐green crystalline substance melts at 161–163 °C. The ultraviolet spectrum shows maxima at 263 and 363 nm. Flavomycoin is soluble in polar organic solvents but insoluble in water and unpolar solvents. Flavomycoin is active against dermatophytes, pathogenic and non‐pathogenic yeasts, filamentous fungi and protozoa. The LD 50 is 24 mg/kg mice, i.p.