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Effect of rifampicin on stability and transfer of R‐factors
Author(s) -
Krčméry V.,
Janoušková J.
Publication year - 1971
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19710110204
Subject(s) - rifampicin , escherichia coli , salmonella , rna polymerase , microbiology and biotechnology , antibiotics , chemistry , dna , biology , bacteria , gene , biochemistry , genetics
Rifampicin LEPETIT, an antibiotic known to interfere with the activity of DNA‐dependent bacterial RNA polymerase, prevented the conjugational transfer of R‐factors in Salmonella typhimurium and Escherichia coli , and showed appreciable accumulation of R— variants in R + cultures. The drug was active in concentrations from 0.25 to 5.0 μg/ml while there was no influence on the viable count of the R + cultures. Although the concentrations of rifampicin found to be active in R + strains of enterobacteria are about 10 times higher than those found to be active in staphylococci by JOHNSTON and RICHMOND (1970), the sub‐bacteriostatic concentrations of the drug were effective enough to eliminate R‐factors and to prevent their transfer from the donor cells studied.