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A simple method for detection of penicillinase‐negative variants among large numbers of penicillinase‐producing staphylococcal colonies
Author(s) -
Borowski Jerzy
Publication year - 1964
Publication title -
zeitschrift für allgemeine mikrobiologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0044-2208
DOI - 10.1002/jobm.19640040204
Subject(s) - penicillin , microbiology and biotechnology , staphylococcus aureus , beta lactamase , biology , mutant , antibiotics , bacteria , escherichia coli , gene , genetics
As has been shown by the studies of BARBER (1948, 1949), FAIRBROTHER et al. (1954). BONDI et al. (1953), HAMBURGER et al. (1958, 1960) and by BOROWSKI (1963a, 1963b), penicillinase‐producing staphylococci may give rise to penicillinase‐negative mutants displaying full sensitivity to penicillin. BOROWSKI (1963) reported that strains yielding penicillinase‐negative mutants in appreciable numbers are found most frequently among staphylococci of phage group I. HAMBURGER et al. (1958, 1960), and BOROWSKI (1963) isolated penicillin‐sensitive variants from the organs of infected animals which were challenged with penicillinase‐producing Staphylococcus aureus strains.