Open AccessRole of antibiotic envelopes in preventing cardiac implantable electronic device infection: A meta‐analysis of 14 859 procedures
Author(s) -
Kumar Ashish,
Doshi Rajkumar,
Shariff Mariam
Publication year - 2020
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1002/joa3.12262
Subject(s) - medicine , meta analysis , relative risk , confidence interval , antibiotics , subgroup analysis , antibiotic prophylaxis , medline , intensive care medicine , microbiology and biotechnology , political science , law , biology
We conducted an updated meta‐analysis assessing the role of antibiotic envelopes in preventing Cardiac implantable electronic devices (CIED)‐related infections as compared to standard infection prevention strategies. Methods A systematic search was conducted on Medline/PubMed and EMBASE/Ovid database. We used Mantel‐Haenszel method with fixed‐effect model to compute risk ratio (RR) with 95% confidence interval (CI). We also performed subgroup and trial sequential analysis on the data. Results Antibiotic envelope reduced the risk of both all infections [RR: 0.41, CI: 0.31‐0.54, P < .05, I 2 = 75%, χ 2 P < .05] and major infections [RR: 0.48, CI: 0.32‐0.70, P < .05, I 2 = 60%, χ 2 P = .04]. Conclusion Prophylactic use of antibiotic envelopes as an adjuvant therapy to standard infection prevention strategies, helps in reducing the risk of CIED infections.