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Convergent influence of the central nucleus of the amygdala and the paraventricular hypothalamic nucleus upon brainstem autonomic neurons as revealed by c‐fos expression and anatomical tracing
Author(s) -
Petrov T.,
Krukoff T. L.,
Jhamandas J. H.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490420612
Subject(s) - brainstem , nucleus , parvocellular cell , central nucleus of the amygdala , catecholaminergic , neuroscience , solitary tract , catecholaminergic cell groups , anterograde tracing , hypothalamus , medulla , rostral ventrolateral medulla , amygdala , retrograde tracing , dorsal raphe nucleus , medulla oblongata , chemistry , biology , medicine , anatomy , central nervous system , dopamine , serotonergic , receptor , serotonin
Combinations of anatomical tracing with detection of Fos (the protein product of the immediate early gene c‐fos) consequent to the stimulation of the central nucleus of the amygdala were used to explore the possibility that the hypothalamic paraventricular nucleus participates in the activation of brainstem neurons in the nucleus of the solitary tract and ventrolateral medulla. After injections of the anterograde tracer Phaseolus vulgaris leucoagglutinin in the paraventricular nucleus, labeled fibers and varicosities were found to impinge on catecholaminergic and non‐catecholaminergic Fos‐positive neurons in the brainstem. After injections of a retrograde tracer in the nucleus of the solitary tract or ventrolateral medulla, we observed that some of the Fos‐positive neurons within the parvocellular paraventricular nucleus that project to the brainstem were catecholaminergic or oxytocinergic. The results indicate that direct and indirect inputs from the amygdala may influence the activity of autonomic neurons in the brainstem. The paraventricular nucleus, via its direct projections onto catecholaminergic and non‐catecholaminergic neurons, may participate in activation of brainstem neurons. Activated catecholaminergic and oxytocinergic parvocellular neurons in the paraventricular nucleus may be involved in the transmission of autonomic signals from the amygdala toward the brainstem. ©1995 Wiley‐Liss, Inc.