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Developmental changes of epidermal growth factor‐like immunoreactivity in the human fetal brain
Author(s) -
Kato M.,
Mizuguchi M.,
Takashima S.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490420407
Subject(s) - epidermal growth factor , gestation , cerebrum , immunohistochemistry , fetus , biology , human brain , endocrinology , medicine , pathology , pregnancy , neuroscience , central nervous system , cell culture , immunology , genetics
We investigated the immunohistochemical localization of epidermal growth factor (EGF) in the developing human brain from 6 weeks of gestation to 3 months postpartum. EGF‐like immunoreactivity varied in its localization and intensity according to the stage of development. At 10‐20 weeks of gestation, EGF‐like immunoreactivity appeared in proliferating and migrating cells in the cerebrum, disappeared thereafter, and appeared again in cortical neurons after 27 weeks of gestation. Astrocytes also showed EGF‐like immunoreactivity from 27 weeks of gestation. These results suggest developmental regulation of EGF expression in the human brain, suggesting Its physiological role in both neuronal and glial cells. © 1995 Wiley‐Liss, Inc.