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Gene therapy in the central nervous system: Direct versus indirect gene delivery
Author(s) -
Ridet J.L.,
Privat A.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490420302
Subject(s) - genetic enhancement , transgene , central nervous system , viral vector , gene delivery , biology , gene , genetically modified organism , transplantation , neuroscience , cell therapy , computational biology , neural stem cell , cell , stem cell , microbiology and biotechnology , medicine , genetics , recombinant dna
Over the last decade, the combination of molecular biology and cell transplantation techniques has given rise to a powerful method for gene therapy. The implantation of genetically modified cultured cells has been extensively used in the central nervous system (CNS) in various experimental models of neurologic disorders. More recently, viral and chemical methods have been developed to further efforts to shuttle transgenes into the relatively inaccessible brain. Adenoviral and liposomal synthetic vectors carry transgenes into neural tissue in situ and are beginning to show promise as new methods for CNS therapy. © 1995 Wiley‐Liss, Inc.