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Ligands for EPH‐related tyrosine kinase receptors are developmentally regulated in the CNS
Author(s) -
Carpenter M. K.,
Shilling H.,
Vandenbos T.,
Beckmann M. P.,
Cerretti D. P.,
Kott J. N.,
Westrum L. E.,
Davison B. L.,
Fletcher F. A.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490420207
Subject(s) - erythropoietin producing hepatocellular (eph) receptor , olfactory bulb , receptor tyrosine kinase , central nervous system , biology , eph receptor a2 , hippocampus , receptor , neuroscience , ephrin , tyrosine kinase , tropomyosin receptor kinase c , receptor protein tyrosine kinases , microbiology and biotechnology , kinase , growth factor , platelet derived growth factor receptor , genetics
Elk is a member of the eph family of receptor‐like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expression of elk, LERK‐1, and LERK‐2 RNAs is high in all regions examined in the embryonic and postnatal rat brain and decreases to low levels with age. One exception is the adult olfactory bulb which continues to express a moderate level of LERK‐2. In contrast, moderate LERK‐4 expression was limited to the developing hippocampus and cerebral cortex. These data indicate that elk and some of the LERKs may play a role in nervous system development, maintenance, and/or regeneration. © 1995 Wiley‐Liss, Inc.