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Distribution of erb‐b2, erb‐b3, and erb‐b4 in the developing avian nervous system
Author(s) -
Francoeur J. R.,
Richardson P. M.,
Dunn R. J.,
Carbonetto S.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490410614
Subject(s) - neuregulin , receptor , receptor tyrosine kinase , biology , epidermal growth factor , neuregulin 1 , nervous system , microbiology and biotechnology , neuroglia , central nervous system , kinase , neuroscience , genetics
The neuregulin proteins (GGF/ARIA/NDF/Heregulin) are pleiotrophic growth and differentiation factors whose receptors, erb‐B2, erb‐B3, and erb‐B4, are members of the epidermal growth factor receptor family of receptor tyrosine kinases. With western blots, we have examined the developmental and regional distribution of these receptors within the brain and sciatic nerve of chick embryos. The receptors erb‐B2, erb‐B3, and erb‐B4 are development and spatially regulated within the nervous system. In addition, cultures enriched for neurons or glia indicate that erb‐B2 and erb‐B4 are found in both neurons and glia, whereas erb‐B3 is found in glia alone. © 1995 Wiley‐Liss, Inc.