Deciphering the native GABA A  receptor: Is there hope? | Zendy

Yeh H. H. | Zendy; Grigorenko E. V. | Zendy

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Deciphering the native GABA A receptor: Is there hope?

Author(s) -

Yeh H. H.,

Grigorenko E. V.

Publication year - 1995

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490410502

Subject(s) - gabaa receptor , gabaa rho receptor , receptor , protein subunit , neuroscience , biology , biochemistry , gene

The bewildering number of GABA A receptor subunits, their regionally dependent expression in the brain, and their supernumerary expression in single cells present major challenges in studying the function of native GABA A receptors. Which subunit combinations actually exist in native neurons? In this mini‐review, GABA A receptor subunit diversity is considered in light of using the wealth of “structure‐function” information gained from studying recombinant receptor to predict the subunit composition and functional properties of native GABA A receptors. © 1995 Wiley‐Liss, Inc.

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