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Deciphering the native GABA A receptor: Is there hope?
Author(s) -
Yeh H. H.,
Grigorenko E. V.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490410502
Subject(s) - gabaa receptor , gabaa rho receptor , receptor , protein subunit , neuroscience , biology , biochemistry , gene
The bewildering number of GABA A receptor subunits, their regionally dependent expression in the brain, and their supernumerary expression in single cells present major challenges in studying the function of native GABA A receptors. Which subunit combinations actually exist in native neurons? In this mini‐review, GABA A receptor subunit diversity is considered in light of using the wealth of “structure‐function” information gained from studying recombinant receptor to predict the subunit composition and functional properties of native GABA A receptors. © 1995 Wiley‐Liss, Inc.