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Platelet‐derived growth factor is a survival factor for PSA‐NCAM + oligodendrocyte pre‐progenitor cells
Author(s) -
Grinspan J. B.,
Franceschini B.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490410414
Subject(s) - neural cell adhesion molecule , precursor cell , growth factor , microbiology and biotechnology , progenitor cell , platelet derived growth factor receptor , biology , myelin , platelet derived growth factor , cell adhesion , stem cell , cell , neuroscience , biochemistry , central nervous system , receptor
Mature oligodendroglia, which synthesize and express lipids and proteins characteristic of myelin, are generated from precursor cells which are formed in germinal matrix, then migrate widely through the neuraxis. We now demonstrate that these precursor cells can be recognized at a very early stage by their surface expression of polysialylated neural cell adhesion molecules (PSA‐NCAM), and only later bind anti ganglioside antibodies that had previously been used to recognize “O‐2A” oligodendroglial precursor cells. PSA‐NCAM expression by these cells is likely to be of functional significance, since a recent study demonstrated that O‐2A cells become immobile when stripped of PSA‐NCAM. Platelet‐derived growth factor (PDGF) proved to be a survival factor for these PSA‐NCAM + cells, and in a defined medium, PDGF was sufficient to ensure maturation of immunopurified PSA‐NCAM + cells to oligodendroglia. © 1995 Wiley‐Liss, Inc.