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Modulatory actions of gamma aminobutyric acid (GABA) on GABA type a receptor subunit expression and function
Author(s) -
Schousboe A.,
Redburn D. A.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490410102
Subject(s) - gabaa receptor , protein subunit , aminobutyric acid , receptor , gamma aminobutyric acid , chemistry , gabaa rho receptor , function (biology) , neuroscience , gaba receptor , pharmacology , microbiology and biotechnology , biology , biochemistry , gene
Gamma aminobutyric acid (GABA) is present in the central nervous system (CNS) during very early embryogenesis. It is therefore likely to play a role not only as a neurotransmitter but also as a signal molecule for neuronal differentiation, growth, and development. It has been firmly established that formation of synapses is strengthened by GABA, and the expression of certain subunits of the GABA type A (GABA A ) receptor complex is clearly promoted by GABA. This latter effect of GABA may have profound implications for the functional activity of GABAergic synapses since the pharmacological properties of GABAA receptors are governed by the subunit composition of the receptor complex. Dynamic changes in GABA A receptor expression and diversity during development and differentiation may therefore play important roles for the inhibitory potential of the CNS during mature stages. © 1995 Wiley‐Liss, Inc.