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Expression of bcl‐2 inhibits necrotic neural cell death
Author(s) -
Kane D. J.,
Örd T.,
Anton R.,
Bredesen Dale E.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490400216
Subject(s) - apoptosis , programmed cell death , necrosis , neural cell , microbiology and biotechnology , cell , biology , haematopoiesis , glutathione , cancer research , chemistry , biochemistry , genetics , enzyme , stem cell
Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto‐oncogene bcl‐2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl‐2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcl‐2 does not inhibit the cellular death program directly; rather, bcl‐2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others. © 1995 Wiley‐Liss, Inc.