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Peripheral myelin protein 22: Facts and hypotheses
Author(s) -
Suter Ueli,
Snipes G. J.
Publication year - 1995
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490400202
Subject(s) - peripheral myelin protein 22 , myelin , context (archaeology) , peripheral nervous system , neuroscience , biology , peripheral , sensory system , genetics , immunology , central nervous system , medicine , paleontology
Mutations affecting the peripheral myelin protein 22 (PMP22) gene are associated with inherited motor and sensory neuropathies in mouse ( Trembler and Trembler‐J ) and human (Charcot‐Marie‐Tooth disease type 1A and Dejerine‐Sottas syndrome). Although genetic studies have established a critical role of PMP22 in the formation and/or maintenance of myelin in the peripheral nervous system, the biological function of PMP22 in myelin and in non‐myelin forming cells remains largely enigmatic. In this Mini Review, we will summarize the current knowledge about PMP22 and discuss its hypothetical function(s) in a broad context. © 1995 Wiley‐Liss, Inc.