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Presence of axonal paried helical filament‐tau in Alzheimer's disease: Submicroscopic localization
Author(s) -
Bondareff W.,
Harrington C. R.,
McDaniel S. W.,
Wischik C. M.,
Roth M.
Publication year - 1994
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490380609
Subject(s) - neuroscience , protein filament , disease , alzheimer's disease , physics , medicine , psychology , chemistry , pathology , biochemistry
While normal adult tau protein is found typically in axons, paired helical filament (PHF) tau has been shown immunohistochemically to be in the somatodendritic compartment in Alzheimer's disease (AD). The small amount of PHF‐tau (8‐‐11%) found in white matter with immunochemical methods is shown here by immunoelectron microscopy to be located in axons. It is localized to straight filament variants of PHFs. The small amount of PHF‐tau in white matter, therefore, appears not to result from the contamination of immunochemical preparations but to be an integral constituent of affected axons in AD. © 1994 Wiley‐Liss, Inc.