G O , a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse | Zendy

Schmidt C. J. | Zendy; Zubiaur M. | Zendy; Valenzuela D. | Zendy; Neer E. J. | Zendy; Dräger U. C. | Zendy

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G O , a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse

Author(s) -

Schmidt C. J.,

Zubiaur M.,

Valenzuela D.,

Neer E. J.,

Dräger U. C.

Publication year - 1994

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490380208

Subject(s) - neuroblast , gap 43 protein , neurite , immunohistochemistry , biology , embryonic stem cell , microbiology and biotechnology , protein subunit , nervous system , embryo , neuroscience , immunology , neurogenesis , biochemistry , gene , in vitro

The developmental pattern of expression of the G protein α O subunit and GAP43 were compared by immunohistochemical staining of mouse embryos. Staining for α O and GAP43 was identical and detected throughout the developing nervous system, and the antigens first appeared in neurons at the beginning of neuronal differentiation. GAP43 and α O were not detected in regions containing only neuroblasts. These observations suggest that α O and GAP43 may not be required for the decision to pass from neuroblast to differentiated neuron, but may play a role in signal transduction during early neuronal development. © 1994 Wiley‐Liss, Inc.

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