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G O , a guanine nucleotide binding protein, is expressed during neurite extension in the embryonic mouse
Author(s) -
Schmidt C. J.,
Zubiaur M.,
Valenzuela D.,
Neer E. J.,
Dräger U. C.
Publication year - 1994
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490380208
Subject(s) - neuroblast , gap 43 protein , neurite , immunohistochemistry , biology , embryonic stem cell , microbiology and biotechnology , protein subunit , nervous system , embryo , neuroscience , immunology , neurogenesis , biochemistry , gene , in vitro
The developmental pattern of expression of the G protein α O subunit and GAP43 were compared by immunohistochemical staining of mouse embryos. Staining for α O and GAP43 was identical and detected throughout the developing nervous system, and the antigens first appeared in neurons at the beginning of neuronal differentiation. GAP43 and α O were not detected in regions containing only neuroblasts. These observations suggest that α O and GAP43 may not be required for the decision to pass from neuroblast to differentiated neuron, but may play a role in signal transduction during early neuronal development. © 1994 Wiley‐Liss, Inc.