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Culture model for the study of cerebral malaria: Antibodies from Plasmodium falciparum ‐infected comatose patients inhibit the dendritic development of Purkinje cells
Author(s) -
Calvet M.C.,
Druilhe P.,
CamachoGarcia R.,
Calvet J.
Publication year - 1993
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490360214
Subject(s) - cerebral malaria , plasmodium falciparum , malaria , antibody , immunology , virology , inhibitory postsynaptic potential , stimulation , in vitro , biology , medicine , neuroscience , biochemistry
The in vitro development of kitten Purkinje cells was inhibited by sera or IgG from cerebral malaria (CM) patients but not by sera from acute non‐complicated malaria (NCM) cases. This inhibitory effect, quantified by computer‐assisted methods, concerned the dendritic (though not the axonal) development and was found to be related to the presence in CM sera of self‐reactive antibodies of the IgG class. These results suggest that protection acquired against the major complication of Plasmodium falciparum malaria may correspond to the repression of an abnormal stimulation of autoreactive B cells. © 1993 Wiley‐Liss, Inc.