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Neuron‐oligodendroglial interactions during central nervous system development
Author(s) -
Hardy R.,
Reynolds R.
Publication year - 1993
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490360202
Subject(s) - myelinogenesis , neuroscience , biology , neuron , central nervous system , lineage (genetic) , myelin , oligodendrocyte , genetics , gene
It is well established that a variety of growth factors influence the differentiation of oligodendroglial lineage cells in culture, although little information is available concerning the role and source of these factors in vivo. Developing oligodendroglia are almost constantly in a neuronal environment and would be expected to respond to a variety of signals from neurons that affect their survival, migration, division, maturation and myelin production. However, very little is known about the specific interactions that occur between these two cell types. Here we review the experimental evidence for the influence of neurons on oligodendroglial differentiation, including studies on the effects of both soluble factors and contact dependent events. We also propose a scheme for the control of myelinogenesis via both internal and external signals. © 1993 Wiley‐Liss, Inc.