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Alteration of carnosine expression in olfactory system of mouse after unilateral naris closure and partial bulbectomy
Author(s) -
Sakai M.,
Nagatsu I.
Publication year - 1993
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490340608
Subject(s) - olfactory bulb , carnosine , olfactory system , tyrosine hydroxylase , neuroscience , dopaminergic , biology , immunocytochemistry , olfaction , medicine , dopamine , endocrinology , chemistry , central nervous system
To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but immunoreactivity of tyrosine hydroxylase (TH), the rate‐limiting enzyme for biosynthesis of dopamine in dopaminergic neurons, decreased dramatically in periglomerular neurons. This behavior of carnosine is consistent with that reported for the olfactory marker protein (OMP). On the other hand, following partial lesion of the olfactory bulb, ordinary to strong carnosine expression was seen in newly innervated glomeruli that exceeded that seen in the conventional targets. Ectopic, TH‐positive, periglomerular cell‐like neurons appeared around the newly formed glomeruli. These data suggest that carnosine may have some role in regulating TH expression in post‐synaptic neurons. © 1993 Wiley‐Liss, Inc.