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Receptor neuron losses result in decreased cytochrome P‐450 immunoreactivity in associated non‐neuronal cells of mouse olfactory mucosa
Author(s) -
Walters E.,
Buchheit K.,
Maruniak J. A.
Publication year - 1992
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490330113
Subject(s) - olfactory mucosa , neuron , receptor , neuroscience , biology , microbiology and biotechnology , cytochrome , olfactory receptor , olfactory system , pathology , medicine , biochemistry , enzyme
Immunohistochemical and immunoblot analyses were used to investigate nasal cytochrome P‐450 distribution in mice with either unilateral naris closure for 3, 4, or 5 months, or olfactory bulbectomy. P‐450 immunoreactivity was observed only in the supporting cells and Bowman's glands of the olfactory mucosa. Immunoreactivity was clearly reduced in rostral regions of the open‐side olfactory mucosa where losses of receptor neurons resulted from 3 to 5 months of closure. Closed‐side immunoreactivity was similar to controls. In 4 month closure animals that had regrown their receptor neurons, open‐side immunoreactivity was comparable to controls. Olfactory bulbectomy also depressed P‐450 immunoreactivity. These data suggest that presence or absence of receptor neurons markedly affects P‐450 expression in nonneuronal cells of the olfactory mucosa. © 1992 Wiley‐Liss, Inc.