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Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells
Author(s) -
Foreman P. J.,
Taglialatela G.,
Jackson G. R.,
PerezPolo J. R.
Publication year - 1992
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490310108
Subject(s) - nerve growth factor , dexamethasone , endocrinology , medicine , chromaffin cell , glucocorticoid , glucocorticoid receptor , messenger rna , receptor , biology , adrenal medulla , catecholamine , biochemistry , gene
Abstract Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytoma cells. Following administration of dexamethasone (1 μM) there is a decline in NGFR mRNA expression. More importantly, administration of dexamethasone appears to block the NGF‐mediated induction of NGFR when both agents are administered simultaneously. These data support the hypothesis that glucocorticoids and NGF act in opposition in determination of the phenotype of chromaffin cells.