Sequence of the rabbit neurofilament protein L | Zendy

Soppet D. R. | Zendy; Beasley L. L. | Zendy; Willard M. B. | Zendy

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Sequence of the rabbit neurofilament protein L

Author(s) -

Soppet D. R.,

Beasley L. L.,

Willard M. B.

Publication year - 1991

Publication title -

journal of neuroscience research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.72

H-Index - 160

eISSN - 1097-4547

pISSN - 0360-4012

DOI - 10.1002/jnr.490300106

Subject(s) - neurofilament , rabbit (cipher) , cdna library , complementary dna , microbiology and biotechnology , biology , sequence (biology) , nucleic acid sequence , peptide sequence , protein primary structure , biochemistry , gene , immunohistochemistry , immunology , statistics , mathematics

In the course of screening a rabbit brain cDNA library with a probe for the H neurofilament protein, we identified a neurofilament L‐cDNA. Its nucleotide sequence is 88% identical to that of human, indicating that L is highly conserved among species. The similarities between the sequences of L from rabbit and mouse suggest that the species‐specific accumulation of neurofilaments that occurs in rabbit during aluminum intoxication is not a consequence of the primary structure of L.

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