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Sequence of the rabbit neurofilament protein L
Author(s) -
Soppet D. R.,
Beasley L. L.,
Willard M. B.
Publication year - 1991
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490300106
Subject(s) - neurofilament , rabbit (cipher) , cdna library , complementary dna , microbiology and biotechnology , biology , sequence (biology) , nucleic acid sequence , peptide sequence , protein primary structure , biochemistry , gene , immunohistochemistry , immunology , statistics , mathematics
Abstract In the course of screening a rabbit brain cDNA library with a probe for the H neurofilament protein, we identified a neurofilament L‐cDNA. Its nucleotide sequence is 88% identical to that of human, indicating that L is highly conserved among species. The similarities between the sequences of L from rabbit and mouse suggest that the species‐specific accumulation of neurofilaments that occurs in rabbit during aluminum intoxication is not a consequence of the primary structure of L.