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Cloning of a human cDNA expressing a high voltage‐activating. Tea‐sensitive, type‐a K + channel which maps to chromosome 1 band p21
Author(s) -
Rudy B.,
Sen K.,
De Miera E. VegaSaenz,
Lau D.,
Ried T.,
Ward D. C.
Publication year - 1991
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490290316
Subject(s) - cloning (programming) , complementary dna , genetics , channel (broadcasting) , biology , microbiology and biotechnology , chromosome , gene , computer science , telecommunications , programming language
Over ten different mammalian genes related to the Drosophila Shaker gene (the Sh gene family) have been identified recently. These genes encode subunits of voltage‐dependent K + channels. The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker‐like genes in Drosophila , Shab, Shaw, and Shal, respectively We report here the cloning of a human K + channel cDNA (HKShIIIC) obtained from a brain stem cDNA library. HKShIIIC transcripts express an atypical voltage‐dependent transient (A‐type) K + current in Xenopus oocytes. This current is activated by large membrane depolarizations and is extremely sensitive to the K + channel blocker TEA unlike most A‐type currents. The gene encoding HKShIIIC maps to chromosome 1p21.

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