Premium
Cerebrospinal fluid catecholamine metabolites in HIV‐infected patients
Author(s) -
Larsson M.,
Hagberg L.,
Forsman A.,
Norkrans G.
Publication year - 1991
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490280313
Subject(s) - homovanillic acid , cerebrospinal fluid , asymptomatic , dementia , medicine , stage (stratigraphy) , catecholamine , aids related complex , human immunodeficiency virus (hiv) , gastroenterology , immunology , viral disease , serotonin , disease , biology , paleontology , receptor
Twenty‐eight HIV‐seropositive individuals—11 asymptomatic cases, 8 with lymphadenopathy syndrome (LAS), and 9 with AIDs—were investigated. Clinical staging of the AIDS dementia complex was done in the 9 AIDS patients. The catecholamine metabolites 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in CSF were determined in all the HIV patients and in 20 healthy volunteers. The CSF MHPG levels did not differ significantly between healthy subjects and HIV‐infected patients at any stage of the infection. The CSF concentrations of HVA differed between the groups only during the AIDS stage. The mean CSF HVA value in the AIDS patients was 42% lower than in the healthy subjects and significantly lower than in any other stage of HIV infection ( P > .01). Patients with signs cf the AIDS dementia complex had reduced CSF HVA levels, but there was no clear relationship between HVA concentration and stage of the AIDS dementia complex.