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Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type β 1 , β 2 , and β 1.2
Author(s) -
Schluesener H. J.
Publication year - 1991
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490280218
Subject(s) - multiple drug resistance , glioblastoma , decapentaplegic , transforming growth factor , cancer research , biology , bone morphogenetic protein , gene , microbiology and biotechnology , gene expression , drug resistance , genetics , enhancer
The transforming growth factors type β 1 , β 2 and β 1.2 suppress multidrug transport in human pat‐1 glioblastoma cells and even in cells that strongly over‐express mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport.