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Cholinergic receptors in human brain: Effects of aging and alzheimer disease
Author(s) -
Giacobini E.
Publication year - 1990
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490270416
Subject(s) - neuroscience , cholinergic , alzheimer's disease , receptor , disease , human brain , brain aging , medicine , psychology , cognition
A general review of cholinergic receptors in human brain is presented. The paper focuses upon changes in normal aging brain and in Alzheimer disease. Studies from five different approaches are reported: (1) molecular biology; (2) receptor binding studies; (3) studies with specific neurotoxins; (4) immunocyto‐chemistry; and (5) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological Alzheimer brain with regard to cholinergic receptor localization, distribution, and function.