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Neonatal hyperthyroidism in the rat produces an increase in the activity of microperoxisomal marker enzymes coincident with biochemical signs of accelerated myelination
Author(s) -
Adamo A. M.,
Aloise P. A.,
Soto E. F.,
Pasquini J. M.
Publication year - 1990
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490250312
Subject(s) - myelinogenesis , myelin , glycerophospholipids , dihydroxyacetone phosphate , population , endocrinology , medicine , plasmalogen , enzyme , myelin basic protein , chemistry , biology , biochemistry , central nervous system , myelin sheath , phospholipid , environmental health , membrane
The effect of neonatal hyperthyroidism produced by injection of tri‐iodothyronine (T 3 ) on myelination and on the microperoxisomal population of the brain was studied in young rats. Data on the lipid composition of myelin show that myelinogenesis starts earlier in treated animals. In coincidence with the early appearance of myelin, there is an increase in the population of brain microperoxisomes, indicated by the increase in the activity of two enzymes that have been shown to be located in these organelles: catalase and acyl CoA‐dihydroxyacetone phosphate acyl transferase. Double‐label experiments using (1,2,3‐ 3 H) and (2‐ 3 H) glycerol to study the synthesis of glycerophospholipids throug the dihydroxyacetone phosphate (DHAP) pathway give further support to the above‐mentioned findings and suggest that there is an active participation of microperoxisomes in the synthesis of myelin lipids during the period of myelin formation.