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125 I‐β‐nerve growth factor binding is reduced in rat brain after stress exposure
Author(s) -
Taglialatela G.,
Angelucci L.,
Ramacci M. T.,
Foreman P. J.,
PerezPolo J. R.
Publication year - 1990
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490250309
Subject(s) - nerve growth factor , basal forebrain , hippocampus , cerebellum , medicine , endocrinology , forebrain , central nervous system , cholinergic neuron , cholinergic , basal (medicine) , neuroscience , cortex (anatomy) , receptor , chemistry , biology , insulin
In the central nervous system (CNS), the presence of nerve growth factor (NGF) and its receptor, NGFR, in cholinergic neurons has been demonstrated. In this study we report that, after exposure to stress, there was a reduction in total binding of NGF in the hippocampus and basal forebrain of 3.5‐month‐old rats without significant changes in the frontal cortex or cerebellum. Chronic treatment with acetyl‐l‐carnitine (ALCAR), that prevents some age‐related impairments of CNS, for 1.5 months, decreased NGF binding in hippocampus and basal forebrain but abolished the stress‐related reduction of NGF binding observed in the hippocampus of untreated rats.