Premium
Characterization of HNK‐1 bearing glycoproteins in human peripheral nerve myelin
Author(s) -
Van Den Berg L. H.,
Sadiq S. A.,
Thomas F. P.,
Latov Norman
Publication year - 1990
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490250305
Subject(s) - bearing (navigation) , glycoprotein , myelin , peripheral nerve , peripheral , neuroscience , microbiology and biotechnology , medicine , biology , anatomy , computer science , central nervous system , artificial intelligence
The HNK‐1 carbohydrate epitope, which is shared by several members of the immunoglobulin gene superfamily, is also the target epitope for IgM anti‐MAG autoantibodies in patients with demyelinating neuropathy. By Western blot analysis, there are 7 HNK‐1 immunoreactive glycoproteins in human peripheral nerve myelin, two of which have previously been identified as the myelin associated glycoprotein (MAG) and the Po glycoprotein. In this study, the remaining HNK‐1 bearing glycoprotein bands were characterized by immunoblot and NH 2 ‐terminal sequence analysis, and were all identified as degradation products or aggregates of the Po glycoprotein. MAG and Po are therefore the only HNK‐1 bearing glycoproteins in human peripheral nerve myelin.