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Modification of serotonergic innervation of the rat spinal cord dorsal horn after neonatal capsaicin treatment
Author(s) -
Marlier L.,
Rajaofetra N.,
Poulat P.,
Privat A.
Publication year - 1990
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490250114
Subject(s) - serotonergic , capsaicin , spinal cord , dorsum , french horn , serotonin , medicine , neuroscience , anesthesia , anatomy , biology , psychology , receptor , pedagogy
Newborn rats were treated with Capsaicin. Seven weeks later, calcitonin gene‐related peptide, substance P, and serotonin were detected immunocytochemically in the dorsal horn of the spinal cord. Peptide immunostaining, presumably located in primary afferents, was reduced in intensity, whereas the pattern of serotonin innervation was modified, suggesting a secondary reorganization due to the lesion of afferents. The possible mechanisms of this reorganization are discussed.