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Platelet‐activating factor stimulates a Fos/Jun/AP‐1 transcriptional signaling system in human neuroblastoma cells
Author(s) -
Squinto S. P.,
Block A. L.,
Braquet P.,
Bazan N. G.
Publication year - 1989
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/jnr.490240414
Subject(s) - neuroblastoma , transcription factor , platelet activating factor , biology , microbiology and biotechnology , antagonist , platelet activating factor receptor , signal transduction , gene , c fos , receptor , phenotype , gene expression , cancer research , cell culture , immunology , biochemistry , genetics
Platelet‐activating factor (PAF) elicits a rapid and transient activation of the proto‐oncogenes c‐ fos and c‐ jun in SH‐SY5Y neuroblastoma cells, but only to a minor extent in Molt‐4 T‐lymphocytes. This effect is inhibited by pretreatment of cells with the PAF antagonist BN 52021, suggesting the involvement of a specific receptor. Moreover, PAF treatment can activate gene expression through an AP‐1 element, and we propose that genomic trans ‐activation may occur in target genes containing a functional AP‐1 transcription sequence. These results may further under standing of the molecular mechanisms by which PAF contributes to long‐term phenotypic changes in the nervous system.